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Phyllanthus niruri  L., a well-known medicinal plant, has been used as a folk antitumor remedy in the worldwide scale. However, the antitumor components in  P. niruri  have not been reported. In order to verify the antitumor components of  P. niruri  and the plants which have the high content of these components, we isolated the antitumor components with bioguided fraction and isolation, by different chromatographic methods from the ethyl acetate fraction of  P. niruri. , and identified them as ethyl brevifolincarboxylate and corilagin by  1 H-NMR,  13 C-NMR, 2D-NMR, and mass spectrometric analyses. Cell cytotoxicity assays showed that corilagin has broad-spectrum antitumor activity, a better antitumor potential, and lower toxicity in normal cells. Besides, the coefficient of drug interaction (CDI) of 10  μ M corilagin and 20  μ M cDDP reached up to 0.77, which means corilagin can promote the antitumor activity of cDDP. Furthermore, by the extensive screening among 10 species of plants reported to contain corilagin, we found that  Dimocarpus longan  Lour. has the maximum content of corilagin. In conclusion, corilagin is the major active antitumor composition in  P. niruri.  L. on HCC cells and has high content in  D. longan .

Bioguided Fraction and Isolation of the Antitumor Components fromPhyllanthus niruriL.