English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Our search for new antibiotics led to the syntheses and biological evaluation of new classes of dicarboxylic acid analogues. The syntheses involve nucleophilic addition of different substituted benzylamine, aniline, alkylamine, and 4-hydroxyl-L-proline with carbamoylbenzoic acid. The results of the antimicrobial activity as indicated by the zone of inhibition (ZOI) showed that  Z    10   is the most active against  Pseudomonas aeruginosa  (32 mm) and least active against  Candida stellatoidea  (27 mm) and Vancomycin Resistant  Enterococci (VRE)  (27 mm), while  Z    7   shows the least zone of inhibition (22 mm) against Methicillin Resistant  Staphylococcus aureus (MRSA) . The minimum inhibition concentration (MIC) determination reveals that  Z    10   inhibits the growth of tested microbes at a low concentration of 6.25  μ g/mL, while  Z    9   and  Z    12   inhibits the growth of most microbes at a concentration of 12.5  μ g/mL, recording the least MIC. The Minimum Bactericidal/Fungicidal Concentration (MBC/MFC) results revealed that  Z    10   has the highest bactericidal/fungicidal effect on the test microbes, at a concentration of 12.5  μ g/mL, with the exception of  Candida stellatoidea  and Vancomycin Resistant  Enterococci (VRE)  with MBC/MFC of 25  μ g/mL. The result of this investigation reveals the potential of the target compounds ( Z    1 – 3 , 5 , 7 – 12  ) in the search for new antimicrobial agents.

international journal of medicinal chemistry

Syntheses and Antibiotic Evaluation of 2-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mo stretchy="false">{</mml:mo></mml:mrow></mml:math>[(2R,4R)-4-Carboxy-2-hydroxypyrrolidin-1-yl]carbonyl<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mrow><mml:mo stretchy="false">}</mml:mo></mml:mrow></mml:math>benzene-1,5-dicarboxylic Acids and 2-Carbamoylbenzene-1,5-dicarboxylic Acid Analogues

Syntheses and Antibiotic Evaluation of 2-{[(2R,4R)-4-Carboxy-2-hydroxypyrrolidin-1-yl]carbonyl}benzene-1,5-dicarboxylic Acids and 2-Carbamoylbenzene-1,5-dicarboxylic Acid Analogues