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In this study, the vitamin D 3  plus nicotine (VDN) model of rats was used to prove that H 2 S alleviates vascular calcification (VC) and phenotype transformation of vascular smooth muscle cells (VSMC). Besides, H 2 S can also inhibit endoplasmic reticulum stress (ERS) of calcified aortic tissues. The effect of H 2 S on alleviating VC and phenotype transformation of VSMC can be blocked by TM, while PBA also alleviated VC and phenotype transformation of VSMC that was similar to the effect of H 2 S. These results suggest that H 2 S may alleviate rat aorta VC by inhibiting ERS, providing new target and perspective for prevention and treatment of VC.

Hydrogen Sulfide Improves Vascular Calcification in Rats by Inhibiting Endoplasmic Reticulum Stress