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The essential oil of  Daucus carota  subsp.  carota  from Portugal, with high amounts of geranyl acetate (29.0%),  α -pinene (27.2%), and 11 α H-himachal-4-en-1 β -ol (9.2%), was assessed for its biological potential. The antimicrobial activity was evaluated against several Gram-positive and Gram-negative bacteria, yeasts, dermatophytes, and  Aspergillus  strains. The minimal inhibitory concentration (MIC) and minimal lethal concentration (MLC) were evaluated showing a significant activity towards Gram-positive bacteria (MIC = 0.32–0.64  μ L/mL),  Cryptococcus neoformans  (0.16  μ L/mL), and dermatophytes (0.32–0.64  μ L/mL). The inhibition of the germ tube formation and the effect of the oil on  Candida albicans  biofilms were also unveiled. The oil inhibited more than 50% of filamentation at concentrations as low as 0.04  μ L/mL (MIC/128) and decreased both biofilm mass and cell viability. The antioxidant capacity of the oil, as assessed by two  in chemico  methods, was not relevant. Still, it seems to exhibit some anti-inflammatory potential by decreasing nitric oxide production around 20% in LPS-stimulated macrophages, without decreasing macrophages viability. Moreover, the oils safety profile was assessed on keratinocytes, alveolar epithelial cells, macrophages, and hepatocytes. Overall, the oil demonstrated a safety profile at concentrations below 0.64  μ L/mL. The present work highlights the bioactive potential of  D. carota  subsp.  carota  suggesting its industrial exploitation.

New Claims for Wild Carrot (Daucus carotasubsp.carota) Essential Oil