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Leishmaniasis is a disease that is a significant problem for people, especially in tropical regions of the world. Current drug therapies to treat the disease are expensive, not very effective, and/or of significant side effects. A series of alkyl bisphosphonate compounds and one amino bisphosphonate compound, as well as alendronate and zoledronate, were tested as potential agents against  Leishmania tarentolae . Also, two polyoxometalates (POMs) with nitrogen-containing bisphosphonate ligands, vanadium/alendronate (V 5 (Ale) 2 ) and vanadium/zoledronate (V 3 (Zol) 3 ), were tested against  L. tarentolae  and compared to the results of the alendronate and zoledronate ligands alone. Of the compounds evaluated in this study, the V 5 (Ale) 2  and V 3 (Zol) 3  complexes were most effective in inhibiting the growth of  L. tarentolae . The V 5 (Ale) 2  complex had a larger impact on cell growth than either alendronate or orthovanadate alone, whereas zoledronate itself has a significant effect on cell growth, which may contribute to the activity of the V 3 (Zol) 3  complex.

Studies of the Effectiveness of Bisphosphonate and Vanadium-Bisphosphonate CompoundsIn Vitroagainst AxenicLeishmania tarentolae