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Previous studies indicated that these genetic elements could be involved in the regulation of lysogenization and prophage induction processes. The effects were dramatic in Shiga toxin-converting phage Φ24 B  after treatment with oxidative stress-inducing agent, hydrogen peroxide, while they were less pronounced in bacteriophage  λ  and in both phages irradiated with UV. The hydrogen peroxide-caused prophage induction was found to be RecA-dependent. Importantly, in hydrogen peroxide-treated  E. coli  cells lysogenic for either  λ  or Φ24 B , deletion of the  exo-xis  region resulted in a significant decrease in the levels of expression of the S.O.S. regulon genes. Moreover, under these conditions, a dramatic decrease in the levels of expression of phage genes crucial for lytic development (particularly  xis, exo, N, cro, O, Q , and  R ) could be observed in Φ24 B -, but not in  λ -bearing cells. We conclude that genes located in the  exo-xis  region are necessary for efficient expression of both host S.O.S regulon in lysogenic bacteria and regulatory genes of Shiga toxin-converting bacteriophage Φ24 B .

The Role of theExo-XisRegion in Oxidative Stress-Mediated Induction of Shiga Toxin-Converting Prophages