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Background . Drug resistance is a major challenge in antibiotic chemotherapy. Assessing resistance profiles of pathogens constitutes an essential surveillance tool in the epidemiology and control of infectious diseases, including Buruli ulcer (BU) disease. With the successful definitive management of BU using rifampicin and streptomycin, little attention had been paid to monitoring emergence of resistant  Mycobacterium ulcerans (M. ulcerans)  isolates in endemic communities. This study investigated the susceptibility profiles of  M. ulcerans  isolates from two BU endemic areas in Ghana to streptomycin and rifampicin.  Methods . The antibiotic susceptibility of seventy (70)  M. ulcerans  isolates to rifampicin and streptomycin was determined simultaneously at critical concentrations of 40  µ g/mL and 4  µ g/mL, respectively, by the Canetti proportion method.  Results . Resistance to rifampicin was observed for 12 (17.1%)  M. ulcerans  isolates tested, whilst 2 (2.9%) showed resistance to streptomycin. None of the isolates tested showed dual resistance to both rifampicin and streptomycin.  Conclusion . Outcomes from this study may not be reflective of all BU endemic communities; it, however, provides information on the resistance status of the isolates, which is useful for monitoring of  M. ulcerans , as well as BU disease surveillance and control.

Susceptibility Profiles ofMycobacterium ulceransIsolates to Streptomycin and Rifampicin in Two Districts of the Eastern Region of Ghana