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Background . The most prominent variant surface antigens (VSAs) of  Plasmodium falciparum  are the var gene-encoded  Plasmodium falciparum  erythrocyte membrane protein 1 (PfEMP1) family, which serves as a parasite-sequestering ligand to endothelial cells. In this study we have examined the antibody reactivity of autologous plasma from symptomatic and asymptomatic malaria infected children against the infected erythrocytes' surface antigens using flow cytometry.  Methods . Ethidium-bromide-labelled erythrocytic mature forms of  P. falciparum  parasites obtained from symptomatic and asymptomatic children were sequentially incubated with autologous plasma and fluorescein isothiocyanate-conjugated (FITC) antihuman IgG. Plasma antibody reactivity was detected by flow cytometry.  Results . Asymptomatic children had more prevalence of trophozoites in peripheral blood (66%) compared to symptomatic children (16%),  p  = 0.002. The mean percentage of infected RBCs reacting with autologous sera was 89.78 among symptomatic children compared to 79.62 among asymptomatic children ( p  = 0.09). Moreover, the mean fluorescence intensity (MFI) in the asymptomatic was significantly higher compared to symptomatic children ( p  value = 0.040).  Conclusion . Variant surface antigens on  Plasmodium falciparum  infected RBCs from symptomatic malaria children tend to be better recognized by IgG antibodies. This may suggest a role of some IgG antibodies in severity of malaria.

mediators of inflammation

The Association of High Prevalence of Trophozoites in Peripheral Blood with Lower Antibody Response toP. falciparumInfected Erythrocytes among Asymptomatic Children in Sudan