English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Although hypoxic environments have been known to regulate the migratory ability of bone marrow-derived mesenchymal stem cells (BM-MSCs), which is a critical factor for maximizing the therapeutic effect, the underlying mechanisms remain unclear. Therefore, we aimed to confirm the effect of hypoxia-inducible factor-1 α  (HIF-1 α ) on the migration of BM-MSCs and to analyze the interaction between HIF-1 α  and integrin-mediated signals. Hypoxia-activated HIF-1 α  significantly increased BM-MSC migration. The expression of integrin  α   4  was decreased in BM-MSCs by increased HIF-1 α  under hypoxia, whereas the expression of Rho-associated kinase 1 (ROCK1) and Rac1/2/3 was increased. After downregulation of HIF-1 α  by YC-1, which is an inhibitor of HIF-1 α , BM-MSC migration was decreased via upregulation of integrin  α   4  and downregulation of ROCK1 and Rac1/2/3. Knockdown of integrin  α   4  by integrin  α   4  siRNA (siITGA4) treatment increased BM-MSC migration by upregulation of ROCK1, Rac1/2/3, and matrix metalloproteinase-2 regardless of oxygen tension. Moreover, siITGA4 treatment increased HIF-1 α  expression and augmented the translocation of HIF-1 α  into the nucleus under hypoxia. Taken together, the alternative expression of HIF-1 α  induced by microenvironment factors, such as hypoxia and integrin  α   4 , may regulate the migration of BM-MSCs. These findings may provide insights to the underlying mechanisms of BM-MSC migration for successful stem cell-based therapy.

Hypoxia Inducible Factor-1αRegulates the Migration of Bone Marrow Mesenchymal Stem Cells via Integrinα4

Hypoxia Inducible Factor-1αRegulates the Migration of Bone Marrow Mesenchymal Stem Cells via Integrinα₄