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Objective . Obesity is a well-known risk factor for thrombotic complications. The aim of the present study was to determine the frequency of thrombosis related  ABO ,  F5 ,  MTHFR,  and  FGG  gene polymorphisms in morbidly obese patients and compare them with the group of nonobese individuals.  Methods . Gene polymorphisms were analyzed in 320 morbidly obese patients (BMI > 40 kg/m 2 ) and 303 control individuals (BMI < 30 kg/m 2 ) of European descent.  ABO  C>T (rs505922),  F5  C>G (rs6427196),  MTHFR  C>T (rs1801133), and  FGG  C>T (rs6536024) SNPs were genotyped by RT-PCR.  Results . We observed a tendency for  MTHFR  rs1801133 TT genotype to be linked with morbid obesity when compared to CC genotype; however, the difference did not reach the significant  P  value (OR 1.84, 95% CI 0.83–4.05,  P  = 0.129). Overall, the genotypes and alleles of rs505922, rs6427196, rs1801133, and rs6536024 SNPs had similar distribution between morbidly obese and nonobese control individuals. Distribution of height and weight means among individuals carrying different rs505922, rs6427196, rs1801133, and rs6536024 genotypes did not differ significantly.  Conclusions . Gene polymorphisms  ABO  C>T (rs505922),  F5  C>G (rs6427196),  MTHFR  C>T (rs1801133), and  FGG  C>T (rs6536024) were not associated with height, weight, or morbid obesity among European subjects.

Thrombosis RelatedABO,F5,MTHFR,andFGGGene Polymorphisms in Morbidly Obese Patients