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We read with great interest the article showing that streptozotocin- (STZ-) induced diabetic rats given puerarin can significantly reduce the serum levels of insulin, glycated hemoglobin, PGE2, endothelin, H2O2, and NO, improve the pathological alterations, and inhibit the expression of ICAM-1, LOX-1, and NOX2 [1]. In addition, puerarin strongly reduced the number of cells showing positive staining for ICAM-1, NOX2, NOX4, and NF-κB p65. Interestingly, Li et al. also showed that STZ-induced diabetes mellitus and aorta lesion can be improved by treatment with puerarin, where puerarin is able to downregulate the levels of cholesterol, low density lipoprotein, P-selectin, oxidative low density lipoprotein, and the expression of VCAM in the aorta which were significantly inhibited [2]. These data indicated that puerarin has played a certain role in preventing aorta or vessels by inhibiting expression of adhesion molecules.

Comment on “Puerarin Improves Diabetic Aorta Injury by Inhibiting NADPH Oxidase-Derived Oxidative Stress in STZ-Induced Diabetic Rats”