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The present study aimed to examine the protective role of  Spirulina platensis  ( S. platensis ) against arsenic-induced testicular oxidative damage in rats. Arsenic (in the form of NaAsO 2  at a dose of 6.3 mg/kg body weight for 8 weeks) caused a significant accumulation of arsenic in testicular tissues as well as a decrease in the levels of testicular superoxide dismutase (SOD), catalase (CAT), reduced glutathione, and zinc. Moreover, it significantly decreased plasma testosterone, luteinizing hormone (LH), triiodothyronine (T 3 ), and thyroxine (T 4 ) levels and reduced sperm motility and sperm count. Arsenic (AS) led to a significant increase in testicular malondialdehyde (MDA), tumour necrosis factor alpha (TNF- α ), nitric oxide (NO), and sperm abnormalities.  S. platensis  at a dose of 300 mg/kg was found to attenuate As-induced oxidative stress, testicular damage, and sperm abnormalities by its potent antioxidant activity.  S. platensis  may represent a potential therapeutic option to protect the testicular tissue from arsenic intoxication.

Antioxidant Potential ofSpirulina platensisMitigates Oxidative Stress and Reprotoxicity Induced by Sodium Arsenite in Male Rats