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Reactive oxygen species (ROS) and nitrogen species have an indispensable role in regulating cell signalling pathways, including transcriptional control via hypoxia inducible factor-1 α  ( HIF-1α ). Hyperbaric oxygenation treatment (HBO 2 ) increases tissue oxygen content and leads to enhanced ROS production. In the present study DSS-induced colitis has been employed in BALB/c mice as an experimental model of gut mucosa inflammation to investigate the effects of HBO 2  on  HIF-1α , antioxidative enzyme, and proinflammatory cytokine genes during the colonic inflammation. Here we report that HBO 2  significantly reduces severity of DSS-induced colitis, as evidenced by the clinical features, histological assessment, impaired immune cell expansion and mobilization, and reversal of  IL-1β ,  IL-2 , and  IL-6  gene expression. Gene expression and antioxidative enzyme activity were changed by the HBO 2  and the inflammatory microenvironment in the gut mucosa. Strong correlation of  HIF-1α  mRNA level to  GPx1 ,  SOD1 , and  IL-6  mRNA expression suggests involvement of  HIF-1α  in transcriptional regulation of these genes during colonic inflammation and HBO 2 . This is further confirmed by a strong correlation of  HIF-1α  with known target genes VEGF and  PGK1 . Results demonstrate that HBO 2  has an anti-inflammatory effect in DSS-induced colitis in mice, and this effect is at least partly dependent on expression of  HIF-1α  and antioxidative genes.

mediators of inflammation

Anti-Inflammatory Effects of Hyperbaric Oxygenation during DSS-Induced Colitis in BALB/c Mice Include Changes in Gene Expression of<i>HIF-1<i>α</i></i>, Proinflammatory Cytokines, and Antioxidative Enzymes

Anti-Inflammatory Effects of Hyperbaric Oxygenation during DSS-Induced Colitis in BALB/c Mice Include Changes in Gene Expression ofHIF-1α, Proinflammatory Cytokines, and Antioxidative Enzymes