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Purpose . To detect changes in optic nerve head (ONH) vascularization in glaucoma patients using spectral-domain OCT angiography (OCT-A).  Material and Method . Fifty glaucoma patients and 30 normal subjects were evaluated with OCT-A (AngioVue®, Optovue). The total ONH vessel density and temporal disc vessel density were measured. Clinical data, visual field (VF) parameters, and spectral-domain OCT evaluation (RNFL: retinal nerve fiber layer thickness, GCC: ganglion cell complex thickness, and rim area) were recorded for glaucoma patients. Correlations among total and temporal ONH vessel density and structural and VF parameters were analyzed.  Results . In the glaucoma group, total and temporal ONH vessel density were reduced by 24.7% (0.412 versus 0.547;  p  < 0.0001) and 22.88% (0.364 versus 0.472;  p  = 0.001), respectively, as compared with the control group. Univariate analysis showed significant correlation between rim area (mm 2 ) and temporal ONH vessel density ( r  = 0.623;  p  < 0.0001) and total ONH vessel density ( r  = 0.609;  p  < 0.0001). Significant correlations were found between temporal and total ONH vessel density and RNFL, GCC, VF mean deviation, and visual field index.  Conclusion . In glaucoma patients OCT-A might detect reduced ONH blood vessel density that is associated with structural and functional glaucomatous damage. OCT-A might become a useful tool for the evaluation of ONH microcirculation changes in glaucoma.

Optic Disc Vascularization in Glaucoma: Value of Spectral-Domain Optical Coherence Tomography Angiography