English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

This study was conducted to investigate the effects of vanadium pentoxide (V 2 O 5 ), ascorbic acid (AA), and alpha-tocopherol ( α -TOH) on apoptotic, cytotoxic, and genotoxic activity. Groups of five Hsd:ICR mice were treated with the following: (a) vehicle, distilled water; (b) vehicle, corn oil; (c) AA, 100 mg/kg intraperitoneally (ip); (d)  α -TOH, 20 mg/kg by gavage; (e) V 2 O 5 , 40 mg/kg by ip injection; (f) AA + V 2 O 5 ; and (g)  α -TOH + V 2 O 5 . Genotoxic damage was evaluated by examining micronucleated polychromatic erythrocytes (MN-PCE) obtained from the caudal vein at 0, 24, 48, and 72 h after treatments. Induction of apoptosis and cell viability were assessed at 48 h after treatment in nucleated cells of peripheral blood. Treatment with AA alone reduced basal MN-PCE, while V 2 O 5  treatment marginally increased MN-PCE at all times after injection. Antioxidants treatments prior to V 2 O 5  administration decreased MN-PCE compared to the V 2 O 5  group, with the most significant effect in the AA + V 2 O 5  group. The apoptotic cells increased with all treatments, suggesting that this process may contribute to the elimination of the cells with V 2 O 5 -induced DNA damage (MN-PCE). The necrotic cells only increased in the V 2 O 5  group. Therefore, antioxidants such as AA and  α -TOH can be used effectively to protect or reduce the genotoxic effects induced by vanadium compounds like V 2 O 5 .

oxidative medicine and cellular longevity

<i>In Vivo</i>Effects of Vanadium Pentoxide and Antioxidants (Ascorbic Acid and Alpha-Tocopherol) on Apoptotic, Cytotoxic, and Genotoxic Damage in Peripheral Blood of Mice

In VivoEffects of Vanadium Pentoxide and Antioxidants (Ascorbic Acid and Alpha-Tocopherol) on Apoptotic, Cytotoxic, and Genotoxic Damage in Peripheral Blood of Mice