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Objective . To investigate the expression of miR-192 and its significance in diabetic nephropathy (DN) patients.  Methods . 464 patients with type 2 diabetes mellitus (T2DM) were divided into normal albuminuria group (NA,  n  = 157), microalbuminuria group (MA,  n  = 159), and large amount of albuminuria group (LA,  n  = 148). 127 healthy persons were selected as the control group (NC,  n  = 127). The serum miR-192 levels were detected by Real-Time PCR and transforming growth factor- β 1 (TGF- β 1) and fibronectin (FN) were detected by enzyme-linked immunosorbent assay. The relationships among these parameters were analyzed by Pearson correlation analysis and multiple linear regression analysis.  Results . The miR-192 in the LA group was significantly lower than other groups, which was lower in the MA group than in the NA group ( P  < 0.01). The TGF- β 1 and FN in the LA group were significantly higher than other groups, which were higher in the MA group than in the NA group ( P  < 0.01). The expression of miR-192 was negatively correlated with TGF- β 1, FN, and Ln (UACR) and miR-192, TGF- β 1, and FN were independent relevant factors affecting Ln (UACR) in T2DM ( P  < 0.01).  Conclusions . These findings indicate that the levels of miR-192 were lower accompanied by the decrease of urine albumin creatinine ratio (UACR) and the association between miR-192 and nephritic fibrosis in DN.

The Expression of miR-192 and Its Significance in Diabetic Nephropathy Patients with Different Urine Albumin Creatinine Ratio