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Inhibitor of DNA binding 2 (ID2) is a helix-loop-helix transcriptional repressor rhythmically expressed in many adult tissues. Our previous studies have demonstrated that  Id2  null mice have sex-specific elevated glucose uptake in brown adipose tissue (BAT). Here we further explored the role of  Id2  in the regulation of core body temperature over the circadian cycle and the impact of  Id2  deficiency on genes involved in insulin signaling and adipogenesis in BAT. We discovered a reduced core body temperature in  Id2 −/− mice. Moreover, in  Id2 −/− BAT, 30 genes including  Irs1 ,  PPAR s, and  PGC-1 s were identified as differentially expressed in a sex-specific pattern. These data provide valuable insights into the impact of  Id2  deficiency on energy homeostasis of mice in a sex-specific manner.

Impaired Thermogenesis and a Molecular Signature for Brown Adipose Tissue inId2Null Mice