English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Background. Recent evidence demonstrated that the circulating levels of omentin-1 are related to the presence of ischemic heart disease and heart failure. However, omentin-1 plasma levels in patients with nonischemic dilated cardiomyopathy (DCM), which is the most common etiology of heart failure, have yet to be investigated. Methods. Plasma levels of omentin-1 and adiponectin were measured in 100 patients with DCM and 45 healthy controls. Results. Plasma omentin-1 levels significantly decreased in DCM patients compared with the control group, whereas adiponectin levels significantly increased in DCM patients compared with the control group. Plasma omentin-1 levels were negatively correlated with adiponectin ( R = - 0.376 , P = 0.005 ), C-reactive protein (CRP) ( R = - 0.320 , P = 0.001 ), and N-terminal pro-brain natriuretic peptide (NT-proBNP) ( R = - 0.365 , P = 0.000 ) levels as well as left ventricular end-diastolic diameter (LVEDD) ( R = - 0.200 , P = 0.046 ) but were positively correlated with left ventricular ejection fraction (LVEF) ( R = 0.496 , P = 0.000 ). Plasma adiponectin levels were positively correlated with CRP ( R = 0.273 , P = 0.006 ) and NT-proBNP ( R = 0.329 , P = 0.001 ) levels but were negatively correlated with fasting glucose ( R = - 0.218 , P = 0.029 ) and LVEF ( R = - 0.615 , P = 0.000 ) levels. Furthermore, omentin-1 (OR 0.983, 95% CI 0.970 to 0.996; P = 0.008 ) levels were independently associated with the presence of DCM before NT-proBNP was added. Conclusions. Omentin-1 is a novel biomarker of DCM.

Circulating Omentin-1 Levels Are Decreased in Dilated Cardiomyopathy Patients with Overt Heart Failure