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Candida  is a common opportunistic pathogen during the course of human immunodeficiency virus (HIV) disease progression. Changes in the clinical severity of candidiasis and the  Candida  species prevalence profile may be a reflection of immunological changes in HIV positive patients. The aim of this study was to document the changing pattern of  Candida  species prevalence profile in HIV seropositive patients from a tertiary care hospital in North India. One hundred and twenty HIV seropositive subjects were recruited for  Candida  microbial screening. Clinical specimens including blood, oral swabs, expectorated or induced sputum/bronchoalveolar lavage specimens, and urine were collected depending on the patient's symptoms. A total of 128  Candida  isolates were obtained from 88 cases and 7 different  Candida  species were identified.  C. albicans  (50%) was the most common species isolated followed by  C. glabrata  (17%) and  C. dubliniensis  (12.5%). Other species isolated were  C. parapsilosis  (7.8%),  C. krusei ,  C. tropicalis  (4.6% each), and  C. kefyr  (3%). Strong clinical suspicion along with optimal sampling of an accurate diagnosis of  Candida  species involved would go a long way in decreasing the morbidity associated with non- albicans Candida  species.

CandidaSpecies Prevalence Profile in HIV Seropositive Patients from a Major Tertiary Care Hospital in New Delhi, India