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A novel active contour model is proposed for segmentation images with inhomogeneity. Firstly, fractional order filter is defined by eight convolution masks corresponding to the image orientation in the eight compass directions. Then, the fractional order differentiation image is obtained and applied to the level set method. Secondly, we defined a new energy functional based on local image information and fractional order differentiation image; the proposed model not only can describe the input image more accurately but also can deal with intensity inhomogeneity. Local fitting term can enhance the ability of the model to deal with intensity inhomogeneity. The defined penalty term is used to reduce the occurrence of false boundaries. Finally, in order to eliminate the time-consuming step of reinitialization and ensure stable evolution of level set function, the Gaussian filtering method is used. Experiments on synthetic and real images show that the proposed model is efficient for images with intensity inhomogeneity and flexible to initial contour

Fractional Differentiation-Based Active Contour Model Driven by Local Intensity Fitting Energy