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Asthma is a chronic lung inflammation which affects many people. As current therapies for asthma mainly rely on administration of glucocorticoids and have many side effects, new therapy is needed. In this study, we investigated  Nepeta bracteata  Benth., a traditional Uygur Herb, for its therapeutics effect in OVA induced asthmatic mice model. Treatment of OVA sensitized asthma mice with extract from  Nepeta bracteata  Benth. demonstrated improved lung pathology, as well as reduced infiltration of eosinophil and neutrophil.  Nepeta bracteata  Benth. extract also contributed to the rebalance of Th17/Treg cell via decreasing the Th17 cell and increasing the Treg, which was corresponding with the inhibited Th17 cytokine response and increased IL-10 level. Moreover, the reduced TGF- β  level and Smad2/3 protein level also suggested that  Nepeta bracteata  Benth. extract could inhibit TGF- β  mediated airway remodelling as well. Taken together, these data suggested that  Nepeta bracteata  Benth. may be a novel candidate for future antiasthma drug development.

Inhibition of Asthma in OVA Sensitized Mice Model by a Traditional Uygur Herb Nepeta bracteata Benth.