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Purpose . Pterygium is a serious eye problem in countries with high exposure to UV. However, despite numerous studies, the molecular etiology of pterygium is unclear. Recent studies have indicated that  LATS1  and  LATS2  genes are involved in DDR signaling pathways against continuous UV exposure. Our aim was to evaluate the  LATS1  and  LATS2  promoter methylation with the risk of pterygium formation.  Methods . We evaluated the promoter methylation status of  LATS1  and  LATS2  using methylation-specific PCR technique. Also, mRNA expression of  LATS1  and  LATS2  was assessed in 14 cases of pterygium and 14 normal specimens by real-time PCR.  Results . Promoter methylation of  LATS1  and  LATS2  was detected significantly between pterygium tissues and normal tissues [ LATS1 ; OR = 4.9; 95% CI: 1.54 to 15.48,  P  = 0.003;  LATS2 ; OR = 7.1; 95% CI: 1.53 to 33.19,  P  = 0.004]. The gene expression analysis showed a statistically significant difference between pterygium tissues and healthy controls for both  LATS1  and  LATS2  ( P  < 0.05).  Conclusions . The data of this study is the first report regarding the effect of promoter methylation of the  LATS1  and  LATS2  in the pterygium. To confirm these data, doing further studies in various genetic populations with large sample sizes using advanced molecular techniques is proposed.

Evaluation ofLATS1andLATS2Promoter Methylation with the Risk of Pterygium Formation