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The aim of the study was to estimate association of the extent of angiographically proven coronary artery disease (CAD) with plasma 8-isoprostane F2 (8-iso-PGF2 α ) levels as a reliable marker of lipid peroxidation and serum activity of paraoxonase-1, which demonstrates the ability to protect against lipid oxidation. The study included 105 patients with angiographically documented CAD (CAD+) and 45 patients with negative results of coronary angiography (CAD−). Compared to the control group CAD+ patients were characterized by increased 8-iso-PGF2 α  levels ( P  = 0.007) and reduced activity of PON-1 towards paraoxon (PONase,  P  = 0.002) and phenyl acetate (AREase,  P  = 0.037). Univariate correlation analysis indicated that 8-iso-PGF2 α  concentrations were positively associated with the severity of CAD as evaluated by the Gensini score ( R  = 0.41,  P  < 0.001) while PONase activity ( R  = −0.26,  P  < 0.05) and AREase activity ( R  = −0.23,  P  < 0.05) were inversely correlated with CAD severity. PONase activity and 8-iso-PGF2 α  concentration remained independent determinant of atherosclerosis severity in multiple linear regression after adjusting for age, gender, smoking habits, hypertension, type 2 diabetes, statin therapy, and HDL-C and TAG concentration ( β  coefficients −0.267;  P  < 0.05 and 0.368;  P  < 0.001, resp.). The results suggest that PON-1 activity and 8-iso-PGF2 α  concentration are associated with the presence and extent of coronary stenosis and may be considered additional markers of coronary artery disease.

PON-1 Activity and Plasma 8-Isoprostane Concentration in Patients with Angiographically Proven Coronary Artery Disease