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Diabetes mellitus is a public health problem worldwide. For this reason, ethanolic extract of  Miconia  sp. from Oaxaca, Mexico, was selected in search of an alternative against this disease. The effect of  Miconia  sp. on mRNA expression of PPAR γ  on cell line 3T3-L1, its effect on alpha amylase and alpha glucosidase, lipid accumulation during adipogenesis, and cell viability on VERO cells were evaluated. The mRNA levels of PPAR γ  increased on 1.393 ± 0.008 folds, lipid accumulation was increased by 29.55% with  Miconia  sp. extract and 34.57% with rosiglitazone, and  α -amylase and  α -glycosidase were inhibited with IC 50  values from 28.23 ± 2.15  μ g/mL and 1.95 ± 0.15  μ g/mL, respectively; the IC 50  on antiproliferative activity on VERO cells was 314.54 ± 45.40  μ g/mL. In case of  α -amylase and  α -glycosidase assays, IC 50  (inhibitory concentration 50) refers to necessary extract amounts to inhibit 50% of enzymatic activity. On the other hand, on antiproliferative activity, IC 50  (inhibitory concentration 50) refers to necessary extract amounts to inhibit 50% of cell proliferation. It was concluded that the compounds present in  Miconia  sp. ethanolic extract increase mRNA expression of PPAR γ , inhibit  α -amylase and  α -glucosidase, and increase lipid accumulation. It constitutes an alternative as adjuvant in diabetes mellitus treatment; therefore, we recommend continuing identifying the compounds responsible for its promising in vivo antidiabetic activity.

Miconiasp. Increases mRNA Levels of PPAR Gamma and Inhibits Alpha Amylase and Alpha Glucosidase