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Aberrant activation of the canonical Wnt pathway plays a significant role in cervical cancer (CC). However, limited data show the correlation between the cancer clinicopathological characteristics and the key molecules such as  β -catenin and Wnt inhibitory factor 1 (WIF1). In this study,  β-catenin  and  WIF1  expression were analyzed by immunohistochemistry for 196 patients with CC, 39 with cervical intraepithelial neoplasia (CIN), and 41 with normal cervical epithelium (NCE). Significant overexpression of  β-catenin  was detected in CC (67.9%) when compared to CIN (43.6%) or NCE (34.1%),  p  < 0.01, while low  WIF1  expression was detected in CC (24.0%) when compared to CIN (59.0%) or NCE (58.5%),  p  < 0.001. Negative correlation was shown between  β-catenin  and  WIF1  expression ( r  = −0.637,  p  < 0.001). In addition, multivariate analysis revealed that both lymph node metastasis and  β-catenin  expression were the independent prognostic factors not only for disease-free survival (HR = 5.029,  p  < 0.001; HR = 2.588,  p  = 0.035, resp.), but also for overall survival (HR = 5.058,  p  < 0.001; HR = 2.873,  p  = 0.031, resp.). Our findings indicate that, besides lymph node metastasis,  β -catenin expression may also be a poor prognostic factor for CC while WIF1 could be a potential drug target for treatment of advanced CC.

β-Catenin Expression Negatively Correlates with WIF1 and Predicts Poor Clinical Outcomes in Patients with Cervical Cancer