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Objective . To investigate vascular endothelial function (VEF) responses to a single low-density lipoprotein (LDL) apheresis session in hypercholesterolemic patients undergoing chronic treatment.  Methods . We measured brachial artery flow-mediated dilation (FMD), plasma lipids, vitamin E ( α - and  γ -tocopherol), markers of oxidative/nitrative stress (malondialdehyde (MDA) and nitro- γ -tocopherol (NGT)), and regulators of NO metabolism (arginine (ARG) and asymmetric dimethylarginine (ADMA)) prior to (Pre) and immediately following (Post) LDL apheresis and at 1, 3, 7, and 14 d Post in 5 hypercholesterolemic patients (52 ± 11 y).  Results . Relative to Pre, total cholesterol (7.8 ± 1.5 mmol/L) and LDL-cholesterol (6.2 ± 1.2 mmol/L) were 61% and 70% lower ( P  < 0.01), respectively, at Post and returned to Pre levels at 14 d. Brachial FMD responses (6.9 ± 3.6%) and plasma MDA, ARG, and ADMA concentrations were unaffected by LDL apheresis. Plasma  α -tocopherol,  γ -tocopherol, and NGT concentrations were 52–69% lower at Post ( P  < 0.01), and  α -tocopherol remained 36% lower at 1 d whereas NGT remained 41% lower at d 3.  Conclusions . Acute cholesterol reduction by LDL apheresis does not alter VEF, oxidative stress, or NO homeostasis in patients treated chronically for hypercholesterolemia.

Single Low-Density Lipoprotein Apheresis Does Not Improve Vascular Endothelial Function in Chronically Treated Hypercholesterolemic Patients