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The cyclopentenone prostaglandin 15-deoxy-Δ 12,14 -prostaglandin J 2  (15d-PGJ 2 ) is a natural ligand of peroxisome proliferator-activated receptor gamma (PPAR- γ ) and a potential mediator of apoptosis in cancer cells. In the present study, we evaluated the effect of 15d-PGJ 2  in human thyroid papillary carcinoma cells (TPC-1) using different doses of 15d-PGJ 2  (0.6 to 20  μ M) to determine IC 50  (9.3  μ M) via the MTT assay. The supernatant culture medium of the TPC-1 cells that was treated either with 15d-PGJ 2  or with vehicle (control) for 24 hours was assessed for IL-6 secretion via CBA assay. RT-qPCR was used to evaluate mRNA expression of IL-6, SOCS1, SOCS3, and STAT3. TPC-1 cells treated with 15d-PGJ 2  decreased the secretion and expression of IL-6 and STAT3, while it increased SOCS1 and SOCS3. Overall, we demonstrated that 15d-PGJ 2  downregulated IL-6 signaling pathway and led TPC-1 cells into apoptosis. In conclusion, 15d-PGJ 2  shows the potential to become a new therapeutic approach for thyroid tumors.

15-Deoxy-Δ12,14-prostaglandin J2Induces Apoptosis and Upregulates SOCS3 in Human Thyroid Cancer Cells

15-Deoxy-Δ^12,14-prostaglandin J₂Induces Apoptosis and Upregulates SOCS3 in Human Thyroid Cancer Cells