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The present study aimed to investigate the  in vitro  mutagenic activity of  Origanum majorana  essential oil. The most abundant compounds identified by GC-MS were  γ -terpinene (25.73%),  α -terpinene (17.35%), terpinen-4-ol (17.24%), and sabinene (10.8%). Mutagenicity was evaluated by the  Salmonella /microsome test using the preincubation procedure on TA98, TA97a, TA100, TA102, and TA1535  Salmonella typhimurium  strains, in the absence or in the presence of metabolic activation. Cytotoxicity was detected at concentrations higher than 0.04  μ L/plate in the absence of S9 mix and higher than 0.08  μ L/plate in the presence of S9 mix and no gene mutation increase was observed. For the  in vitro  mammalian cell micronucleus test, V79 Chinese hamster lung fibroblasts were used. Cytotoxicity was only observed at concentrations higher than or equal to 0.05  μ g/mL. Moreover, when tested in noncytotoxic concentrations,  O. majorana  essential oil was not able to induce chromosome mutation. The results from this study therefore suggest that  O. majorana  essential oil is not mutagenic at the concentrations tested in the  Salmonella /microsome and micronucleus assays.

Origanum majoranaEssential Oil Lacks Mutagenic Activity in theSalmonella/Microsome and Micronucleus Assays