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Primary hepatic carcinoma (PHC) is one of the most common malignant tumours in the world. More and more research has shown that As 2 O 3  combined with TACE has a good curative effect in treating PHC. The objectives of this study were to evaluate the therapeutic efficacy and safety of As 2 O 3  combined with TACE in treating PHC. The CNKI, VIP, Wanfang, PubMed, and Cochrane databases were searched from their inception until December 2015. Randomized controlled trials (RCTs) comparing As 2 O 3  combined with TACE versus TACE alone in treating PHC were identified. Stata SE 12.0 was used for data analysis. 17 RCTs with 1055 patients were included. Meta-analysis showed that, compared with TACE alone, As 2 O 3  combined with TACE showed significant effects in improving the clinical efficacy rate ( P  < 0.01), decreasing the value of alpha-fetoprotein ( P  < 0.01), increasing the one-year survival rate ( P  < 0.01), and improving the quality of life of PHC patients ( P  < 0.01). Fifteen studies had mentioned adverse events, but no serious adverse effects were reported in any of the included trials. In conclusion, As 2 O 3  combined with TACE therapy appears to be potentially effective in treating PHC and is generally safe. However, further studies with rigorous designs trials and multiregional cooperation trials are needed.

A Meta-Analysis of Arsenic Trioxide Combined with Transcatheter Arterial Chemoembolization for Treatment of Primary Hepatic Carcinoma