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The objective of this study is to investigate the potential association of the  NLRP3 rs10754558  and  CARD8 rs2043211  polymorphisms with the occurrence and prognosis of CAD. Gene polymorphisms were analyzed using the ABI PRISM-Snapshot multiplex method in 515 CAD patients and 401 control subjects. The serum level of IL-1 β  was investigated by ELISA assays. The clinical endpoints were evaluated during a median follow-up period of 32 months. The  NLRP3 rs10754558  gene polymorphism was significantly associated with the occurrence of CAD, while the  CARD8 rs2043211  gene polymorphism was not involved. Patients carrying G allele of  NLRP3 rs10754558  had more severe coronary artery stenosis. Multivariable analysis revealed a significant association of the G allele with major adverse cardiac event. The serum IL-1 β  concentrations in patients with GG genotype were significantly increased compared with those in the patients with CC genotype. Our findings for the first time show that the  NLRP3  rs10754558 polymorphism is involved in the occurrence of CAD in the Chinese Han population; and G allele can effectively predict clinical outcome of CAD. The G allele susceptibility to CAD is maybe associated with the increased level of serum IL-1 β .

TheNLRP3 rs10754558Polymorphism Is Associated with the Occurrence and Prognosis of Coronary Artery Disease in the Chinese Han Population