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.  Microcos paniculata  is traditionally used for treating diarrhea, wounds, cold, fever, hepatitis, dyspepsia, and heat stroke.  Objective . To investigate the qualitative phytochemical constituents of hydromethanol (HMPB) and petroleum benzene extract of  Microcos paniculata  barks (PBMPB) and to evaluate their antinociceptive and antidiarrheal activities.  Methods . Phytochemical constituents and antinociceptive and antidiarrheal activities were determined and evaluated by different tests such as Molisch's, Fehling's, Mayer's, Wagner's, Dragendorff's, frothing, FeCl 3 , alkali, Pew's, and Salkowski's test, general test of glycosides, Baljet and NH 4 OH test, formalin-induced paw licking, acetic acid-induced writhing, tail immersion, and hot plate tests, and castor oil and MgSO 4  induced diarrheal tests.  Results . These extracts revealed the presence of saponins, flavonoids, and triterpenoids and significantly ( ⁎   P  < 0.05, versus control) reduced paw licking and abdominal writhing of mice. At 30 min after their administration, PBMPB revealed significant increase in latency ( ⁎   P  < 0.05, versus control) in tail immersion test. In hot plate test, HMPB and PBMPB 200 mg/kg showed significant increase in response latency ( ⁎   P  < 0.05, versus control) at 30 min after their administration. Moreover, both extracts significantly ( ⁎   P  < 0.05, versus control) inhibited percentage of diarrhea in antidiarrheal models.  Conclusion.  Study results indicate that  M .  paniculata  may provide a source of plant compounds with antinociceptive and antidiarrheal activities.

biomed research international

Phytochemical Screening and Antinociceptive and Antidiarrheal Activities of Hydromethanol and Petroleum Benzene Extract of<i>Microcos paniculata</i>Barks

Phytochemical Screening and Antinociceptive and Antidiarrheal Activities of Hydromethanol and Petroleum Benzene Extract ofMicrocos paniculataBarks