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. The characterization of genetic profile of  Plasmodium  isolates from different areas could help in better strategies for malaria elimination. This study aimed to compare  P. falciparum  diversity in two African countries.  Methods . Isolates collected from 100 and 73  falciparum  malaria infections in sites of Côte d'Ivoire (West Africa) and Gabon (Central Africa), respectively, were analyzed by a nested PCR amplification of  msp 1 and  msp 2 genes.  Results . The K1 allelic family was widespread in Côte d'Ivoire (64.6%) and in Gabon (56.6%). For  msp 2, the 3D7 alleles were more prevalent (>70% in both countries) compared to FC27 alleles. In Côte d'Ivoire, the frequencies of multiple infections with  msp 1 (45.1%) and  msp 2 (40.3%) were higher than those found for isolates from Gabon, that is, 30.2% with  msp 1 and 31.4% with  msp 2. The overall complexity of infection was 1.66 (SD = 0.79) in Côte d'Ivoire and 1.58 (SD = 0.83) in Gabon. It decreased with age in Côte d'Ivoire in contrast to Gabon.  Conclusion . Differences observed in some allelic families and in complexity profile may suggest an impact of epidemiological facies as well as immunological response on genetic variability of  P. falciparum .

Genetic Polymorphism ofmsp1 andmsp2 inPlasmodium falciparumIsolates from Côte d’Ivoire versus Gabon