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Purpose.   124 I has a half-life of 4.2 days, which makes it suitable for imaging over several days over its uptake and washout phases. However, it has a low positron branching ratio (23%), because of prompt gamma coincidence due to high-energy  γ -photons (602 to 1,691 keV), which are emitted in cascade with positrons.  Methods.  In this study, we investigated the optimal PET energy window for  124 I PET based on image characteristics of reconstructed PET. Image characteristics such as nonuniformities, recovery coefficients (RCs), and the spillover ratios (SORs) of  124 I were measured as described in NEMA NU 4-2008 standards.  Results.  The maximum and minimum prompt gamma coincidence fraction (PGF) were 33% and 2% in 350~800 and 400~590 keV, respectively. The difference between best and worst uniformity in the various energy windows was less than 1%. The lowest SORs of  124 I were obtained at 350~750 keV in nonradioactive water compartment.  Conclusion.  Optimal energy window should be determined based on image characteristics. Our developed correction method would be useful for the correction of high-energy prompt gamma photon in  124 I PET. In terms of the image quality of  124 I PET, our findings indicate that an energy window of 350~750 keV would be optimal.

Comparison of Imaging Characteristics of124I PET for Determination of Optimal Energy Window on the Siemens Inveon PET

Comparison of Imaging Characteristics of¹²⁴I PET for Determination of Optimal Energy Window on the Siemens Inveon PET