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Aims . The association between  Helicobacter pylori  ( H. pylori ) infection and diarrhea-predominant irritable bowel syndrome (IBS-D) is still controversial. Here we performed a retrospective study to explore this issue.  Methods . A total of 502 inpatients with Rome III confirmed IBS-D and known  H. pylori  status from 8 hospitals were enrolled.  H. pylori- positive patients, hospitalized in the recent year, were followed up to evaluate the effects of  H. pylori  eradication on IBS-D clinical course.  Results . Of the 502 IBS-D patients, 206 were  H. pylori -positive, with an infection rate that has no significant difference with that of the general population in Guangdong province ( p  = 0.348). For patients followed up, no significant differences were noted as to overall symptoms ( p  = 0.562), abdominal pain/discomfort ( p  = 0.777), bloating ( p  = 0.736), stool frequency ( p  = 0.835), or stool characteristics ( p  = 0.928) between the  H. pylori- eradicated group and the control group. The results were the same in long-term follow-up patients except the improvement of bloating, which showed that the bloating score in the  H. pylori- eradicated group was significantly lower ( p  = 0.047).  Conclusions . No significant correlation between  H. pylori  infection and IBS-D was noted. Overall, IBS-D patients may not benefit from  H. pylori  eradication.

gastroenterology research and practice

Lack of Association Found between<i>Helicobacter pylori</i>Infection and Diarrhea-Predominant Irritable Bowel Syndrome: A Multicenter Retrospective Study

Lack of Association Found betweenHelicobacter pyloriInfection and Diarrhea-Predominant Irritable Bowel Syndrome: A Multicenter Retrospective Study