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Interleukin-17 contributes to the pathogenesis of type 1 diabetes mellitus (T1DM) and chronic periodontitis (CP). We analyzed  IL-17A  −197A/G and  IL-17F  +7488C/T polymorphisms in T1DM and CP and determined their associations with IL-17 production and occurrence of periopathogens. Totally 154 controls, 125 T1DM, and 244 CP patients were genotyped using 5′ nuclease TaqMan ®  assays. Bacterial colonization was investigated by a DNA-microarray kit. Production of IL-17 after  in vitro  stimulation of mononuclear cells by mitogens and bacteria was examined by the Luminex system. Although no differences in the allele/genotype frequencies between patients with CP and T1DM + CP were found, the  IL-17A  −197 A allele increased the risk of T1DM ( P  < 0.05). Levels of HbA1c were significantly elevated in carriers of the A allele in T1DM patients ( P  < 0.05). Production of IL-17 by mononuclear cells of CP patients (unstimulated/stimulated by  Porphyromonas gingivalis ) was associated with  IL-17A  A allele ( P  < 0.05).  IL-17A  polymorphism increased the number of  Tannerella forsythia  and  Treponema denticola  in patients with CP and T1DM + CP, respectively ( P  < 0.05).  IL-17A  gene variability may influence control of T1DM and the “red complex” bacteria occurrence in patients with CP and T1DM + CP. Our findings demonstrated the functional relevance of the  IL-17A  polymorphism with higher IL-17 secretion in individuals with A allele.

mediators of inflammation

<i>Interleukin-17A</i>Gene Variability in Patients with Type 1 Diabetes Mellitus and Chronic Periodontitis: Its Correlation with IL-17 Levels and the Occurrence of Periodontopathic Bacteria

Interleukin-17AGene Variability in Patients with Type 1 Diabetes Mellitus and Chronic Periodontitis: Its Correlation with IL-17 Levels and the Occurrence of Periodontopathic Bacteria