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Oxidative stress might contribute to the occurrence of cancers, including the hematological ones. Various genetic polymorphisms were shown to increase the quantity of reactive oxygen species, a phenomenon that is able to induce mutations and thus promote cancers. The purpose of the study was to evaluate the association between  CAT  C262T,  GPX1  Pro198Leu,  MnSOD  Ala16Val,  GSTM1, GSTT1,  and  GSTP1  Ile105Val gene polymorphisms and acute myeloid leukemia risk, in a case-control study comprising 102 patients and 303 controls. No association was observed between AML and variant genotypes of  CAT, MnSOD, GSTM1 , and  GSTT1  polymorphisms. Our data revealed a statistically significant difference regarding the frequencies of  GPX1  Pro198Leu and  GSTP1  Ile105Val variant genotypes between AML patients and controls ( p  < 0.001). Our results showed no association in the distribution of any of the  CAT  C262T,  GPX1  Pro198Leu,  GSTM1, GSTT1,  and  GSTP1  polymorphisms regarding age, gender, FAB subtype, cytogenetic risk groups,  FLT3  and  DNMT3  gene mutations, and overall survival. Our data suggests that the presence of variant allele and genotype of  GPX1  Pro198Leu and  GSTP1  Ile105Val gene polymorphisms may modulate the risk of developing AML.

From Six Gene Polymorphisms of the Antioxidant System, Only GPX Pro198Leu and GSTP1 Ile105Val Modulate the Risk of Acute Myeloid Leukemia