English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

We evaluated in the 7-year prospective study whether variants in vitamin D pathway genes and calcium-sensing receptor gene  (CASR)  are determinants of mortality in hemodialysis (HD) patients ( n  = 532). HRM analysis was used for  GC  rs2298849,  GC  rs1155563,  RXRA  rs10776909,  RXRA  rs10881578, and  CASR  rs7652589 genotyping.  GC  rs7041,  RXRA  rs749759,  VDR  rs2228570, and  VDR  rs1544410 were genotyped using PCR-RFLP analysis. The minor allele in  GC  rs2298849 was associated with all-cause mortality in univariate analysis (HR 1.330, 95% CI 1.046–1.692,  P  = 0.020). Bearers of the minor allele in  GC  rs2298849 demonstrated higher infection/neoplasm mortality than major allele homozygotes also in multivariate analysis (HR 2.116, 95% CI 1.096–4.087,  P  = 0.026). Cardiovascular mortality was associated with major homozygosity (CC) in  VDR  rs2228570 (HR 1.896, 95% CI 1.163–3.091,  P  = 0.010). CC genotype patients were more often dyslipidemic than TT genotype subjects (46.1% versus 31.9%,  P  = 0.047). Dyslipidemics showed higher frequency of rs1544410_rs2228570 haplotype AC than nondyslipidemics (26 versus 18%,  P   corr  = 0.005), whereas TT genotype patients were at lower risk of dyslipidemia compared with CC/CT genotype patients (HR 0.59, 95% CI 0.37–0.96,  P  = 0.04). In conclusion,  GC  rs2298849 and  VDR  rs2228570 SNPs are associated with survival on HD.  VDR -related cardiovascular mortality may occur due to connections of rs2228570 with dyslipidemia.

international journal of endocrinology

Polymorphisms of Vitamin D Signaling Pathway Genes and Calcium-Sensing Receptor Gene in respect to Survival of Hemodialysis Patients: A Prospective Observational Study