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Endophytic microbe has been proved to be one of rich sources of bioactive natural products with potential application for new drug and pesticide discovery. One cyclodepsipeptide, beauvericin, was firstly isolated from the fermentation broth of  Fusarium oxysporum  5-19 endophytic on  Edgeworthia chrysantha  Linn. Its chemical structure was unambiguously identified by a combination of spectroscopic methods, such as HRESI-MS and  1 H and  13 C NMR. ESI-MS/MS was successfully used to elucidate the splitting decomposition route of the positive molecule ion of beauvericin. Antimicrobial results showed that this cyclodepsipeptide had inhibitory effect on three human pathogenic microbes,  Candida albicans ,  Escherichia coli , and  Staphylococcus aureus . In particular, beauvericin exhibited the strongest antimicrobial activity against  S. aureus  with MIC values of 3.91  μ M, which had similar effect with that of the positive control amoxicillin.

Isolation and Identification of the Antimicrobial Agent Beauvericin from the EndophyticFusarium oxysporum5-19 with NMR and ESI-MS/MS