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Two important biologically active compounds were isolated from  Mallotus philippensis . The isolated compounds were characterized using spectroanalytical techniques and found to be bergenin ( 1 ) and 11 -O -galloylbergenin ( 2 ). The  in vitro  antioxidant and antiplasmodial activities of the isolated compounds were determined. For the antioxidant potential, three standard analytical protocols, namely, DPPH radical scavenging activity (RSA), reducing power assay (RPA), and total antioxidant capacity (TAC) assay, were adopted. The results showed that compound  2  was found to be more potent antioxidant as compared to  1 . Fascinatingly, compound  2  displayed better EC 50  results as compared to  α -tocopherol while being comparable with ascorbic acid. The antiplasmodial assay data showed that both the compound exhibited good activity against chloroquine sensitive strain of  Plasmodium falciparum  (D10) and IC 50  values were found to be less than 8  μ M. The  in silico  molecular docking analyses were also performed for the determination of binding affinity of the isolated compounds using  P. falciparum  proteins PfLDH and Pfg27. The results showed that compound  2  has high docking score and binding affinity to both protein receptors as compared to compound  1 . The demonstrated biological potentials declared that compound  2  could be the better natural antioxidant and antiplasmodial candidate.

Antioxidant and Antiplasmodial Activities of Bergenin and 11-O-Galloylbergenin Isolated fromMallotus philippensis