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Background . Parkinson's disease (PD) and Alzheimer's disease (AD) share pathological features, including amyloid-beta pathology. Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein (APP), and genetic variations in the processing pathway genes have been found to increase the risk of AD; however, the contribution in PD is unknown.  Methods . The aim of this study was to investigate whether candidate polymorphisms in five genes ( ADAM10 ,  BACE1 ,  BACE2 ,  PSEN2 , and  CLU ) involved in the APP processing pathway affect PD risk in a population-based cohort of patients with incident PD and control subjects from the Norwegian ParkWest study.  Results . We found an association of rs638405 in  BACE1  with increased risk of PD, thus providing a novel link, at the genetic level, between amyloid-beta pathology and PD.

Association of aBACE1Gene Polymorphism with Parkinson’s Disease in a Norwegian Population