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Novel sulfonamides were developed and structures of the new products were confirmed by elemental and spectral analysis (FT-IR, ESI-MS,  1 HNMR, and  13 CNMR). In vitro, developed compounds were screened for their antibacterial activities against medically important gram (+) and gram (−) bacterial strains, namely,  S. aureus ,  B. subtilis ,  E. coli , and  K. pneumoniae . The antibacterial activities have been determined by measuring MIC values ( μ g/mL) and zone of inhibitions (mm). Among the tested compounds, it was found that compounds 5a and 9a have most potent activity against  E. coli  with zone of inhibition: 31 ± 0.12 mm (MIC: 7.81  μ g/mL) and 30 ± 0.12 mm (MIC: 7.81  μ g/mL), respectively, nearly as active as ciprofloxacin (zone of inhibition: 32 ± 0.12 mm). In contrast, all the compounds were totally inactive against the gram (+)  B. subtilis .

biomed research international

Synthesis, Characterization, and Antibacterial Activities of Novel Sulfonamides Derived through Condensation of Amino Group Containing Drugs, Amino Acids, and Their Analogs