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Objective.  Functional dyspepsia (FD) is a frequent clinical finding in western world. The aim of this study is to compare the efficacy of a ginger and artichoke supplementation versus placebo in the treatment of FD.  Methods.  A prospective multicentre, double blind, randomized, placebo controlled, parallel-group comparison of the supplement and placebo over a period of 4 weeks was performed. Two capsules/day were supplied (before lunch and dinner) to 126 FD patients (supplementation/placebo: 65/61).  Results . After 14 days of treatment, only supplementation group (SG) showed a significant amelioration (SG:  α   S  = +1.195 MCA score units (u),  P  = 0.017; placebo:  α   P  = +0.347 u,  P  = 0.513). The intercept ( α ) resulted to be significantly higher in SG than in placebo ( α   S  −  α   P  = +0.848 u,  P  < 0.001). At the end of the study, the advantage of SG versus placebo persists without variation ( β   S  −  β   P  = +0.077 u,  P  = 0.542). In SG, a significant advantage is observed for nausea ( β   S  −  β   P  = −0.398 u,  P  < 0.001), epigastric fullness ( β   S  −  β   P  = −0.241,  P  < 0.001), epigastric pain ( β   S  −  β   P  = −0.173 u,  P  = 0.002), and bloating ( β   S  −  β   P  = −0.167 u,  P  = 0.017).  Conclusions . The association between ginger and artichoke leaf extracts appears safe and efficacious in the treatment of FD and could represent a promising treatment for this disease.

evidence-based complementary and alternative medicine

The Effect of Ginger (<i>Zingiber officinalis</i>) and Artichoke (<i>Cynara cardunculus</i>) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial

The Effect of Ginger (Zingiber officinalis) and Artichoke (Cynara cardunculus) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial