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During amoebic liver abscess (ALA) formation in susceptible animals, immune response is regulated by prostaglandin E 2  (PGE 2 ) dependent mechanisms. The aim of this study was to analyze the effect of misoprostol (MPL), a PGE 1  analogue, on ALA formation in BALB/c mice. Male mice from BALB/c strain were intrahepatically infected with 7.5 × 10 5  trophozoites of  E. histolytica  strain HM1:IMSS and treated with 10 −4  M of MPL daily until sacrifice at 2, 4, and 7 days postinfection (p.i.). ALA formation was evaluated at 2, 4, and 7 days postinfection; trophozoite morphology was analyzed using immunohistochemistry and image analysis. Results showed an increase in frequency of ALA formation in infected and MPL-treated mice only at 2 days p.i. ( P  = 0.03). A significant diminution in the size of trophozoites was detected in abscesses from mice independently of MPL treatment (from 5.8 ± 1.1  µ m at 2 days p.i. to 2.7 ± 1.9  µ m at 7 days p.i.) compared with trophozoites dimensions observed in susceptible hamsters (9.6 ± 2.7  µ m) ( P  < 0.01). These results suggest that MPL treatment may modify the adequate control of inflammatory process to allow the persistence of trophozoites in the liver; however, natural resistance mechanisms cannot be discarded.

Morphological Findings in Trophozoites during Amoebic Abscess Development in Misoprostol-Treated BALB/c Mice