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Background . The aim of this study is to assess renal damage incidence in patients with solitary kidney and to detect factors associated with progression.  Methods . Medical records of 75 patients with solitary kidney were investigated retrospectively and divided into two groups: unilateral nephrectomy (group 1) and unilateral renal agenesis/dysplasia (group 2). According to the presence of kidney damage, each group was divided into two subgroups: group 1a/b and group 2a/b.  Results . Patients in group 1 were older than those in group 2 ( p  = 0.001). 34 patients who comprise group 1a had smaller kidney size ( p  = 0.002) and higher uric acid levels ( p  = 0.028) than those in group 1b at presentation. Uric acid levels at first and last visit were associated with renal damage progression ( p  = 0.004, 0.019). 18 patients who comprise group 2a were compared with those in group 2b in terms of presence of DM ( p  = 0.038), HT ( p  = 0.003), baseline proteinuria ( p  = 0.014), and uric acid ( p  = 0.032) levels and group 2a showed higher rates for each. Progression was more common in patients with DM ( p  = 0.039), HT ( p  = 0.003), higher initial and final visit proteinuria ( p  = 0.014, for both), and higher baseline uric acid levels ( p  = 0.047).  Conclusions . The majority of patients with solitary kidney showed renal damage at presentation. Increased uric acid level is a risk factor for renal damage and progression. For early diagnosis of renal damage and reducing the risk of progression, patients should be referred to a nephrologist as early as possible.

Renal Damage Frequency in Patients with Solitary Kidney and Factors That Affect Progression