English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Studies of chemokine receptors (CKR) in natural killer- (NK-) cells have already been published, but only a few gave detailed information on its differential expression on blood NK-cell subsets. We report on the expression of the inflammatory and homeostatic CKR on normal blood CD56 +low  CD16 +  and CD56 +high   CD16 −/+low  NK-cells. Conventional CD56 +low  and CD56 +high  NK-cells present in the normal PB do express CKR for inflammatory cytokines, although with different patterns CD56 +low  NK-cells are mainly CXCR1/CXCR2 +  and CXCR3/CCR5 −/+ , whereas mostly CD56 +high  NK-cells are CXCR1/CXCR2 −  and CXCR3/CCR5 + . Both NK-cell subsets have variable CXCR4 expression and are CCR4 −  and CCR6 − . The CKR repertoire of the CD56 +low  NK-cells approaches to that of neutrophils, whereas the CKR repertoire of the CD56 +high  NK-cells mimics that of Th1 +  T cells, suggesting that these cells are prepared to migrate into inflamed tissues at different phases of the immune response. In addition, we describe a subpopulation of NK-cells with intermediate levels of CD56 expression, which we named CD56 +int  NK-cells. These NK-cells are CXCR3/CCR5 + , they have intermediate levels of expression of CD16, CD62L, CD94, and CD122, and they are CD57 −  and CD158a − . In view of their phenotypic features, we hypothesize that they correspond to a transitional stage, between the well-known CD56 +high  and CD56 +low  NK-cells populations.

journal of immunology research

Chemokine Receptor Expression on Normal Blood CD56<sup>+</sup>NK-Cells Elucidates Cell Partners That Comigrate during the Innate and Adaptive Immune Responses and Identifies a Transitional NK-Cell Population

Chemokine Receptor Expression on Normal Blood CD56+NK-Cells Elucidates Cell Partners That Comigrate during the Innate and Adaptive Immune Responses and Identifies a Transitional NK-Cell Population

Chemokine Receptor Expression on Normal Blood CD56⁺NK-Cells Elucidates Cell Partners That Comigrate during the Innate and Adaptive Immune Responses and Identifies a Transitional NK-Cell Population