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The role of genetics in progression of cancer is an established fact, and susceptibility risk and difference in outcome to chemotherapy may be caused by the variation in low-penetrance alleles of risk genes. We selected seven genes ( CRP, GPC5, ACTA2, AGPHD1, SEC14L5, RBMS3 , and  GKN1 ) that previously reported link to lung cancer (LC) and genotyped single nucleotide polymorphisms (SNPs) of these genes in a case-control study. A protective allele “C” was found in rs2808630 of the C-reactive protein ( CRP ). Model association analysis found genotypes “T/C” and “C/C” in the dominant model and genotype “T/C” in the overdominant model of rs2808630 associated with reduced LC risk. Gender-specific analysis in each model showed that genotypes “T/T” and “C/C” in rs2352028 of the  Glypican 5  ( GPC5 ) were associated with increased LC risk in males. Logistic regression analysis showed “C/T” genotype carriers of rs4254535 in the  Gastrokine 1  ( GKN1 ) had less likelihood to have chemotherapy response. Our results suggest a potential association between  CRP  and  GPC5  variants with LC risk; variation in  GKN1  is associated with chemotherapy response in the Chinese Han population.

disease markers

Polymorphisms inC-Reactive ProteinandGlypican-5Are Associated with Lung Cancer Risk andGartrokine-1Influences Cisplatin-Based Chemotherapy Response in a Chinese Han Population