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Ethnopharmacological Relevance . The Hugan Qingzhi tablet (HQT) is a traditional Chinese medicine used for treating NAFLD (nonalcoholic fatty liver disease). The present study evaluated the anti-inflammatory effects of HQT in rats with NAFLD.  Materials and Methods . HQT was administered daily to the NAFLD experimental groups. Biochemical markers, histopathological data, and oxidative stress/antioxidant biomarkers were determined. Proinflammatory cytokines interleukin-1 β  (IL-1 β ), tumor necrosis factor  α  (TNF- α ), and interleukin-6 (IL-6) were detected by enzyme-linked immunoassay. Expressions of silent information regulator 1 (SIRT1) and acetylated-nuclear-factor kappaB-p65 (Ac-NF- κ B-p65) were performed by western blotting.  Results . At high and moderate doses, HQT was highly effective in decreasing serum alanine aminotransferase ( P  < 0.01), aspartate aminotransferase ( P  < 0.01), hepatic total cholesterol ( P  < 0.01), triglycerides ( P  < 0.01), and free fatty acid levels ( P  < 0.01). Moreover, high and moderate doses of HQT reduced hepatic levels of the proinflammatory cytokines TNF- α  ( P  < 0.01), IL-1 β  ( P  < 0.01), and IL-6 ( P  < 0.01), enhanced SIRT1 expression, and depressed Ac-NF- κ B-p65 expression at protein level.  Conclusions . In our NAFLD rat model, HQT exerted substantial anti-inflammatory and antioxidant activities, possibly involving the regulation of SIRT1 and Ac-NF- κ B-p65 expression.

Hugan QingzhiExerts Anti-Inflammatory Effects in a Rat Model of Nonalcoholic Fatty Liver Disease