English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Inflammation and tumor hypoxia are intimately linked and breast cancer provides a typical example of an inflammation-linked malignant disease. Indeed, breast cancer progression is actively supported by inflammatory components, including IL-1 β , and by the hypoxia-inducible factor- (HIF-) 1 α . In spite of many attempts where the role of either IL-1 β  or HIF-1 α  was evaluated, detailed mechanisms for their effects on breast cancer cell migration under hypoxia are still unclear. We here report that IL-1 β  increased MDAMB231 cell migration under hypoxic conditions along with HIF-1 α  accumulation and upregulation of CXCR1, which is transcriptionally regulated by HIF-1 α , as well as an increased expression of CXCL8 and NF κ B. In addition, IL-1 β -induced cell migration in hypoxia was not affected when HIF-1 α  was inhibited by either siRNA or Topotecan, well known for its inhibitory effect on HIF-1 α . Of interest, HIF-1 α  inhibition did not reduce NF κ B and CXCL8 expression and the reduction of IL-1 β -induced cell migration under hypoxia was achieved only by pharmacological inhibition of NF κ B. Our findings indicate that inhibition of HIF-1 α  does not prevent the migratory program activated by IL-1 β  in hypoxic MDAMB231 cells. They also suggest a potential compensatory role of NF κ B/CXCL8 pathway in IL-1 β -induced MDAMB231 cell migration in a hypoxic microenvironment.

Interleukin-1βAffects MDAMB231 Breast Cancer Cell Migration under Hypoxia: Role of HIF-1αand NFκB Transcription Factors