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Experimental observations show that calcium signals in response to external stimuli encode information via frequency modulation or alternatively via amplitude modulation. Here, by arguments of bifurcation theory and bifurcation control theorem, the amplitude and frequency manipulation of limit cycle in Shen-Larter cell system are investigated. A nonlinear feedback controller is then applied to the system, in order to assign the peak frequency to a prescribed value, such that bifurcation is minimized or eliminated in the closed-loop system. And numerical simulations are presented in order to illustrate the theoretical analysis.

Physical Manipulation of Calcium Oscillation in Shen-Larter Cell System