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Objective.  To study the effect of different proportions of Huangqi ( Radix Astragali Mongolici ) and Honghua ( Flos Carthami ) injection on  α -glucosidase and  α -amylase activity simultaneously.  Methods.  The injections were prepared according to the standards of the China Food and Drug Administration. The assay for potential  α -glucosidase inhibitors was based on the hydrolysis of 4-methylumbelliferyl- α -D-glucopyranoside (4-MUG). The  α -amylase EnzChek assay kit was used to determine potential  α -amylase inhibitors. Acarbose was the positive control.  Results.  The half maximal (50%) inhibitory concentration (IC 50 ) of acarbose against  α -glucosidase and  α -amylase was (1.8 ± 0.4)  μ g/mL and (227 ± 32)  μ g/mL, respectively. Honghua showed significant inhibition of  α -glucosidase activity compared with Huangqi ( P  < 0.01). Honghua inhibited  α -amylase activity, but Huangqi did not. IC 50 s for  α -glucosidase inhibition by mixtures at 10 : 1, 5 : 1, and 2 : 1 were significantly lower than those at the 20 : 1 mixture ( P  < 0.01).  α -Amylase inhibition by the 2 : 1 mixture was significantly higher than that by the 20 : 1, 10 : 1, and 5 : 1 mixtures at 500  μ g/mL and 1000  μ g/mL ( P  < 0.01), with 5 : 1 significantly higher than 20 : 1 and 10 : 1 at 1000  μ g/mL ( P  < 0.01).  Conclusion.  Honghua significantly inhibited  α -glucosidase activity compared with Huangqi ( P  < 0.01). For simultaneous inhibition of  α -glucosidase and  α -amylase activities, the mixtures at 2 : 1 and 5 : 1 exhibited significant effects compared with those at 20 : 1 ( P  < 0.01).

evidence-based complementary and alternative medicine

Different Proportions of Huangqi (<i>Radix Astragali Mongolici</i>) and Honghua (<i>Flos Carthami</i>) Injection on<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi mathvariant="bold-italic">α</mml:mi></mml:mrow></mml:math>-Glucosidase and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mrow><mml:mi mathvariant="bold-italic">α</mml:mi></mml:mrow></mml:math>-Amylase Activities

Different Proportions of Huangqi (Radix Astragali Mongolici) and Honghua (Flos Carthami) Injection onα-Glucosidase andα-Amylase Activities